How Autoimmune Disease Affects Pregnancy

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Thymic Lesion

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Overview Thymic tumors occupy the anterior mediastinum, which is immediately posterior to the sternum and the anterior surface of the pericardium and great vessels. Tumors of thymic, lymphatic, or germ cell origin most commonly occur in this compartment, although aberrant parathyroid or thyroid tissue masses are sometimes found, along with vascular and mesenchymal tissue masses. (See the images below.) Fairly large thymus in an infant.  View Media Gallery Gross appearance of a thymoma showing distinct multinodularity and scattered, focal cystic changes.  View Media Gallery Thymolymphoma. Chest radiograph shows a large, lobulated mediastinal mass.  View Media Gallery About one half of all thymic tumors are malignant in individuals aged 20-40 years, and one third are malignant in persons younger than 20 years and those older than 40 years. (A malignant thymic tumor is seen in the image below.) Malignant thymoma. Chest CT scan in a 61-year-old man with myasthenia gr
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Advance Treatments

Abstract and Introduction  Abstract Myasthenia gravis (MG) should be classified according to antibody status (acetylcholine, MuSK, LRP4, titin), thymus (hyperplasia, neoplasia, atrophy), age at debut (< or >50 years), symptom localization (generalized, ocular) and severity. With optimal treatment, the prognosis is good in terms of daily functions, quality of life and survival. Symptomatic treatment with acetylcholine esterase is usually combined with immunosuppression. A combination of prednisolone and azathioprine remains the first choice alternative, whereas rituximab is a promising second choice drug for severe generalized MG. Thymectomy is recommended for early-onset, generalized MG and for thymoma MG. In acute exacerbations including MG crisis, intravenous immunoglobulin and plasma exchange have good and similar effects. MG in young females needs therapeutic considerations regarding potential pregnancy. Introduction Myasthenia gravis (MG) is an autoimmune and antib
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Epidemiology Of Myasthenia Gravis

The prevalence of myasthenia gravis in the United States is estimated at 14 to 20 per 100,000 population, approximately 36,000 to 60,000 cases in the United States. However, myasthenia gravis remains underdiagnosed and the prevalence is probably higher. Previous studies have shown that women are more often affected than men. The most common age at onset is the second and third decades in women and the seventh and eighth decades in men. As the population ages, the average age at onset has increased correspondingly, and now males are more often affected than females, and the onset of symptoms is usually after age 50. A 2015 study in acetylcholine receptor antibody (AChR-Abs) positive Caucasian has demonstrated that there is no specific causal gene for myasthenia gravis there are specific regulatory genes that influence immune regulation. In addition, about 3% of the study population had a primary relative with myasthenia gravis suggesting a small but distinct but not direct genetic inf
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