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Thymic Lymphoma

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On CT scans, the thymus is enlarged, symmetrically or asymmetrically; this enlargement often makes it difficult to differentiate the thymus from the enlarged surrounding lymph nodes. At times, differentiating the thymus from a thymoma is difficult, although the clinical picture and the presence of other sites of lymphadenopathy are often helpful in the diagnosis. (See the image below.) Thymolymphoma. Contrast-enhanced CT scan demonstrates a large, lobulated, soft tissue mass in the anterior mediastinum that posteriorly displaces the aorta and pulmonary artery.  View Media Gallery
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Anti-LRP4 Autoantibodies

Abstract INTRODUCTION:  We assessed antibodies against low-density lipoprotein receptor-related protein 4 (LRP4-Ab) in a Chinese population with myasthenia gravis (MG). METHODS:  Serum samples from 116 patients and 80 controls were collected. Acetylcholine receptor antibodies(AChR-Ab) and muscle-specific receptor tyrosine kinase antibodies (MuSK-Ab) were tested using an enzyme-linked immune absorption assay, and LRP4-Ab was identified using a cell-based assay. MG patients with neither AChR-Ab nor MuSK-Ab were defined as double-seronegative MG (dSN-MG). RESULTS:  Two of 116 (1.7%) of all patients and 2 of 50 (1%) dSN-MG patients were positive for LRP4-Ab. These 2 patients had ocular MG. Following treatment with acetylcholinesterase inhibitor and prednisone, both achieved full remission. CONCLUSIONS:  This study shows that LRP4-Ab is a pathogenic antibody in MG. LRP4-MG seems to be characterized by mild disease severity and favorable therapeutic effect in ...
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